Our Methodology
How we translate clinical research into personalised dosage recommendations you can trust.
Literature review
For each substance, we perform a systematic review of PubMed-indexed randomised controlled trials (RCTs), meta-analyses, and systematic reviews. We prioritise human RCTs with ≥ 30 participants over 4 weeks, placebo-controlled designs, and studies published in peer-reviewed journals with an impact factor > 2.
Dose identification
We extract the lowest effective dose (LED) and the dose used in the majority of positive trials. Where official bodies (ISSN, Endocrine Society, NIH Office of Dietary Supplements) have published position statements or dietary reference intakes (DRIs), these take precedence. We never recommend doses exceeding the Tolerable Upper Intake Level (UL) without explicit physician-supervision caveats.
Safety screening
Each substance is reviewed for known drug interactions, contraindicated populations (pregnancy, renal impairment, autoimmune conditions), and adverse event profiles from pharmacovigilance databases. Safety warnings on our pages reflect real, documented risks — not generic liability disclaimers.
Ongoing review
Supplement science evolves rapidly. We review each calculator page when major new RCTs are published or when official guidelines are updated. Last-reviewed dates will be displayed on each page in a future update.
Primary reference databases
Found an error or a more recent study? Contact us — we take accuracy corrections seriously.